GTx - Genome Assembly

DNA GTx Bioinformatics “Genome Assembly and Annotation Service” is a cutting-edge bioinformatics service designed to assist researchers, geneticists, and biologists in analyzing and understanding the complex structure and function of genomes. This service combines advanced computational algorithms and expertise to assemble and annotate genomes, providing valuable insights into genetic composition, gene identification, regulatory elements, and other functional elements.

APPLICATIONS

Comparative genomics and evolutionary studies.

Identification and characterization of novel genes and functional elements.

Investigation of genetic variations and disease-causing mutations.

Development of genetic resources for crop improvement and livestock breeding.

Microbial genomics.

Environmental genomics.

KEY FEATURES

Genome Assembly: DNA GTx Bioinformatics employs state-of-the-art algorithms and methodologies toreconstruct the complete genome sequence from raw sequencing data. We utilize various sequencing technologies,including next-generation sequencing (NGS) and third-generation sequencing (long-read sequencing),both from all existing platforms, to achieve high-quality genome assemblies. This process involves error correction,read alignment, contig assembly, and scaffolding to generate accurate and contiguous genome sequences.

Data Preprocessing: Prior to assembly, the service performs quality control on the raw sequencing data. It includes steps such as trimming low-quality reads, removing sequencing artifacts, and filtering out any potential contaminants. This ensures that only reliable data is used in the assembly process.

De Novo Assembly: The service offers de novo assembly, which is applicable when no reference genome is available. It reconstructs the genome solely based on the sequencing reads, providing valuable insights into novel genomes or organisms with limited genomic information.

Re-sequencing or Reference-Guided Assembly: When a reference genome is available, the service employs alignment- based techniques to map and assemble the sequencing reads against the reference. This approach helps in accurately aligning the reads and resolving complex genomic variations, such as structural variants or copy number variations.

Structural Annotation: DNA GTx Bioinformatics provides comprehensive structural annotation services, which involve the identification and labeling of various genomic features, such as protein-coding genes, non-coding RNAs, repeat elements, transposable elements, and structural variants. DNA GTx Bioinformatics experts use a combination of ab initio prediction algorithms, homology-based methods, and transcriptomic data to ensure accurate and complete annotation of structural elements.

Functional Annotation: Our service includes functional annotation to assign biological meaning to the genomic elements identified during structural annotation. We utilize various databases to annotate gene functions, protein domains, metabolic pathways, and regulatory elements. This information aids in understanding the biological processes, molecular functions, and cellular components associated with the annotated genes.

Functional Annotation: Our service includes functional annotation to assign biological meaning to the genomic elements identified during structural annotation. We utilize various databases to annotate gene functions, protein domains, metabolic pathways, and regulatory elements. This information aids in understanding the biological processes, molecular functions, and cellular components associated with the annotated genes.

Quality Assessment: The service incorporates rigorous quality control measures throughout the assembly and annotation process. Various metrics, such as contiguity, coverage, completeness, and accuracy, are evaluated to ensure reliable and high-quality results.

Comparative Genomics: We offer comparative genomics analysis to identify conserved regions, gene families, and evolutionary relationships between genomes. By comparing the newly assembled genome with existing reference genomes or related species, we can detect synteny, gene duplications, gene losses, and other evolutionary events. This analysis provides valuable insights into the evolutionary history and genetic variation within and between species.

Customization and Integration: The service can be tailored to meet specific needs. It allows researchers to incorporate additional data, such as transcriptomic or epigenomic data, to enhance the accuracy and biological relevance of the assembly and annotation results. Moreover, the service ensures compatibility with various downstream analysis tools and workflows.

Data Visualization and Interpretation: Our service includes intuitive data visualization tools to present the annotated genome in a clear and understandable manner. We generate visual representations, such as genome browsers and interactive plots, to facilitate the exploration and interpretation of genomic data. Our experts also provide detailed reports and summaries, highlighting key findings and implications from the genome assembly and annotation process.

BENEFITS

Accurate and Complete Genomic Information: Our service ensures high-quality genome assemblies and precise annotation of genomic elements, enabling researchers to access accurate and comprehensive genetic information.

Time and Cost Savings: Outsourcing genome assembly and annotation to our service eliminates the need for expensive computational infrastructure and extensive bioinformatics expertise. This saves valuable time and resources for research institutions and/or companies, allowing them to focus on their core objectives.

Expertise and Experience: DNA GTx Bioinformatics team comprises bioinformatics specialists with extensive knowledge and experience in genome assembly and annotation. They stay up-to-date with the latest algorithms and methodologies, ensuring the application of best practices in the field.

Confidentiality and Data Security: We prioritize data confidentiality and security, adhering to strict protocols to protect sensitive genomic data. All data transfer and storage are conducted using secure protocols and encrypted systems.

GTx - Genome Assembly

DNA GTx Bioinformatics “Genome Assembly and Annotation Service” is a cutting-edge bioinformatics service designed to assist researchers, geneticists, and biologists in analyzing and understanding the complex structure and function of genomes. This service combines advanced computational algorithms and expertise to assemble and annotate genomes, providing valuable insights into genetic composition, gene identification, regulatory elements, and other functional elements.

APPLICATIONS

Comparative genomics and evolutionary studies.

Identification and characterization of novel genes and functional elements.

Investigation of genetic variations and disease-causing mutations.

Development of genetic resources for crop improvement and livestock breeding.

Microbial genomics.

Environmental genomics.

KEY FEATURES

Genome Assembly: DNA GTx Bioinformatics employs state-of-the-art algorithms and methodologies toreconstruct the complete genome sequence from raw sequencing data. We utilize various sequencing technologies,including next-generation sequencing (NGS) and third-generation sequencing (long-read sequencing),both from all existing platforms, to achieve high-quality genome assemblies. This process involves error correction,read alignment, contig assembly, and scaffolding to generate accurate and contiguous genome sequences.

Data Preprocessing: Prior to assembly, the service performs quality control on the raw sequencing data. It includes steps such as trimming low-quality reads, removing sequencing artifacts, and filtering out any potential contaminants. This ensures that only reliable data is used in the assembly process.

De Novo Assembly: The service offers de novo assembly, which is applicable when no reference genome is available. It reconstructs the genome solely based on the sequencing reads, providing valuable insights into novel genomes or organisms with limited genomic information.

Re-sequencing or Reference-Guided Assembly: When a reference genome is available, the service employs alignment- based techniques to map and assemble the sequencing reads against the reference. This approach helps in accurately aligning the reads and resolving complex genomic variations, such as structural variants or copy number variations.

Structural Annotation: DNA GTx Bioinformatics provides comprehensive structural annotation services, which involve the identification and labeling of various genomic features, such as protein-coding genes, non-coding RNAs, repeat elements, transposable elements, and structural variants. DNA GTx Bioinformatics experts use a combination of ab initio prediction algorithms, homology-based methods, and transcriptomic data to ensure accurate and complete annotation of structural elements.

Functional Annotation: Our service includes functional annotation to assign biological meaning to the genomic elements identified during structural annotation. We utilize various databases to annotate gene functions, protein domains, metabolic pathways, and regulatory elements. This information aids in understanding the biological processes, molecular functions, and cellular components associated with the annotated genes.

Functional Annotation: Our service includes functional annotation to assign biological meaning to the genomic elements identified during structural annotation. We utilize various databases to annotate gene functions, protein domains, metabolic pathways, and regulatory elements. This information aids in understanding the biological processes, molecular functions, and cellular components associated with the annotated genes.

Quality Assessment: The service incorporates rigorous quality control measures throughout the assembly and annotation process. Various metrics, such as contiguity, coverage, completeness, and accuracy, are evaluated to ensure reliable and high-quality results.

Comparative Genomics: We offer comparative genomics analysis to identify conserved regions, gene families, and evolutionary relationships between genomes. By comparing the newly assembled genome with existing reference genomes or related species, we can detect synteny, gene duplications, gene losses, and other evolutionary events. This analysis provides valuable insights into the evolutionary history and genetic variation within and between species.

Customization and Integration: The service can be tailored to meet specific needs. It allows researchers to incorporate additional data, such as transcriptomic or epigenomic data, to enhance the accuracy and biological relevance of the assembly and annotation results. Moreover, the service ensures compatibility with various downstream analysis tools and workflows.

Data Visualization and Interpretation: Our service includes intuitive data visualization tools to present the annotated genome in a clear and understandable manner. We generate visual representations, such as genome browsers and interactive plots, to facilitate the exploration and interpretation of genomic data. Our experts also provide detailed reports and summaries, highlighting key findings and implications from the genome assembly and annotation process.

BENEFITS

Accurate and Complete Genomic Information: Our service ensures high-quality genome assemblies and precise annotation of genomic elements, enabling researchers to access accurate and comprehensive genetic information.

Time and Cost Savings: Outsourcing genome assembly and annotation to our service eliminates the need for expensive computational infrastructure and extensive bioinformatics expertise. This saves valuable time and resources for research institutions and/or companies, allowing them to focus on their core objectives.

Expertise and Experience: DNA GTx Bioinformatics team comprises bioinformatics specialists with extensive knowledge and experience in genome assembly and annotation. They stay up-to-date with the latest algorithms and methodologies, ensuring the application of best practices in the field.

Confidentiality and Data Security: We prioritize data confidentiality and security, adhering to strict protocols to protect sensitive genomic data. All data transfer and storage are conducted using secure protocols and encrypted systems.